The presence of this polymorphism in CYP2D6 brings about non-operating enzyme variant and should be associated with lowered therapeutic response when handled with codeine.
Lung Troubles. Promethazine/phenylephrine/codeine really should not be used When you have significant bronchial asthma, difficulty respiration, or other lung troubles. Promethazine/phenylephrine/codeine will make these circumstances even worse.
Clients must be advised to report any involuntary muscle mass actions. Prevent extended exposure to the Sunlight.
opioid receptors dispersed all over the central anxious system. The sedative functions of codeine are significantly less powerful than Those people of morphine 18. Codeine may perhaps trigger respiratory process melancholy by the activation of μ-opioid receptors at precise internet sites inside the central nervous program eight.
Codeine is adjusted to morphine in the human body. Lots of people adjust codeine to morphine much more immediately than Other individuals. These men and women are called "extremely-fast metabolizers of codeine". Call your health practitioner instantly should you expertise Intense sleepiness, confusion, or shallow breathing.
Making use of narcotics for years may cause intense constipation. To circumvent this, your medical professional may well immediate you to consider laxatives, consume lots of fluids, or improve the level of fiber in the diet program.
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If you find yourself getting this medication, it is especially crucial that the Health care Specialist know For anyone who is having any with the medicines stated beneath. The next interactions are already picked on the basis of their likely significance and are not always all-inclusive.
Bone-Marrow Melancholy – Promethazine need to be applied with warning in sufferers with bone-marrow despair. Leukopenia and agranulocytosis are actually noted, commonly when promethazine HCl continues to be Utilized in association with other known marrow-poisonous brokers.
Promethazine/phenylephrine/codeine may be employed for other circumstances as determined by your healthcare company.
Pregnancy Assessments: Diagnostic pregnancy exams according to immunological reactions among HCG and anti-HCG may website bring about false-destructive or false-favourable interpretations.
Allergies to Ingredients. People who find themselves allergic to any of the next should not consider promethazine/phenylephrine/codeine.
Promethazine and codeine mixture is utilized To alleviate cough, runny or stuffy nose, sneezing, or other indications because of allergic reactions or the popular cold.
薬物乱用問題は直接摂取以外にもある。コデインを成分とする市販のせき止め薬から化学処理により強力な麻薬デソモルヒネを密造する方法であり、その方法がインターネット経由で広まり、ロシアなどの地域で乱用被害の増加が問題になっている[要出典]。